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National Facility for Gene Function in Health and Disease (NFGFHD)
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Indian Institute of Science Education and Research (IISER), Pune
From Genotype to Phenotype...
ACE2 Knock-Out Model
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In humans, ACE2 protein is involved in SARS-CoV-2 cells entry and responsible for pathology of COVID 19 .
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However, Mice are low-sensitive to SARS-CoV infection, but can be poorly inoculated by the virus.
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So knockout of ACE2 genes in MICE through genome editing will give opportunity to study the viral sensitivity and generation of COVID 19 model .
Availability of mice model
Mice are available for distribution in India for academic research. Please contact us afic@iiserpune.ac.in
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